1U6Q
Substituted 2-Naphthamadine inhibitors of Urokinase
Summary for 1U6Q
Entry DOI | 10.2210/pdb1u6q/pdb |
Related | 1owd 1owe 1owh 1owi 1owj 1sqa |
Descriptor | Urokinase-type plasminogen activator, TRANS-6-(2-PHENYLCYCLOPROPYL)-NAPHTHALENE-2-CARBOXAMIDINE (2 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 1 |
Total formula weight | 27908.87 |
Authors | Bruncko, M.,McClellan, W.,Wendt, M.D.,Sauer, D.R.,Geyer, A.,Dalton, C.R.,Kaminski, M.K.,Nienaber, V.L.,Rockway, T.R.,Giranda, V.L. (deposition date: 2004-07-30, release date: 2004-10-19, Last modification date: 2011-07-13) |
Primary citation | Bruncko, M.,McClellan, W.J.,Wendt, M.D.,Sauer, D.R.,Geyer, A.,Dalton, C.R.,Kaminski, M.A.,Weitzberg, M.,Gong, J.,Dellaria, J.F.,Mantei, R.,Zhao, X.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Bouska, J.,Rockway, T.W.,Giranda, V.L. Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg.Med.Chem.Lett., 15:93-98, 2005 Cited by PubMed: 15582418DOI: 10.1016/j.bmcl.2004.10.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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