1U2Y

In situ extension as an approach for identifying novel alpha-amylase inhibitors, structure containing D-gluconhydroximo-1,5-lactam

1U2Y の概要

• エントリーDOI: 10.2210/pdb1u2y/pdb
• 関連するPDBエントリー: 1CPU 1U30 1U33
• 分子名称: Alpha-amylase, pancreatic, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: glycosidase, human pancreatic alpha-amylase, acarbose, inhibitor, glucosidase, enzyme mechanism, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56420.21

構造登録者

Numao, S.,Li, C.,Damager, I.,Wrodnigg, T.M.,Begum, A.,Overall, C.M.,Brayer, G.D.,Withers, S.G. (登録日: 2004-07-20, 公開日: 2004-09-07, 最終更新日: 2020-07-29)

• 主引用文献: Numao, S.,Damager, I.,Li, C.,Wrodnigg, T.M.,Begum, A.,Overall, C.M.,Brayer, G.D.,Withers, S.G.; In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors.; J.Biol.Chem., 279:48282-48291, 2004; PubMed: 15304511; DOI: 10.1074/jbc.M406804200

実験手法

X-RAY DIFFRACTION (1.95 Å)