1TYE

Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen

1TYE の概要

• エントリーDOI: 10.2210/pdb1tye/pdb
• 関連するPDBエントリー: 1TXV 1TY3 1TY5 1TY6 1TY7
• 分子名称: Integrin alpha-IIb, Integrin beta-3, beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: crystal structure; platelet integrin alphaiibbeta3; fibrinogen binding; allostery; therapeutic antagonism, cell adhesion
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 298452.84

構造登録者

Xiao, T.,Takagi, J.,Coller, B.S.,Wang, J.-H.,Springer, T.A. (登録日: 2004-07-07, 公開日: 2004-10-12, 最終更新日: 2023-08-23)

• 主引用文献: Xiao, T.,Takagi, J.,Coller, B.S.,Wang, J.-H.,Springer, T.A.; Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics; Nature, 432:59-67, 2004; PubMed: 15378069; DOI: 10.1038/nature02976

実験手法

X-RAY DIFFRACTION (2.9 Å)