1TW2

Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET)

1TW2 の概要

• エントリーDOI: 10.2210/pdb1tw2/pdb
• 関連するPDBエントリー: 1QZZ 1R00 1TW3
• 分子名称: Carminomycin 4-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, ... (4 entities in total)
• 機能のキーワード: anthracycline, methyltransferase, methylate, streptomyces, tailoring enzyme, polyketide, s-adenosyl-l-homocystein, structural proteomics in europe, spine, structural genomics, transferase
• 由来する生物種: Streptomyces peucetius
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80248.64

構造登録者

Jansson, A.,Koskiniemi, H.,Mantsala, P.,Niemi, J.,Schneider, G.,Structural Proteomics in Europe (SPINE) (登録日: 2004-06-30, 公開日: 2004-09-14, 最終更新日: 2024-04-03)

• 主引用文献: Jansson, A.,Koskiniemi, H.,Mantsala, P.,Niemi, J.,Schneider, G.; Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products; J.Biol.Chem., 279:41149-41156, 2004; PubMed: 15273252; DOI: 10.1074/jbc.M407081200

実験手法

X-RAY DIFFRACTION (2.5 Å)