1TSQ

CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT

Summary for 1TSQ

Entry DOI	10.2210/pdb1tsq/pdb
Descriptor	Pol polyprotein, AP2V NC-P1 SUBSTRATE PEPTIDE, ACETATE ION, ... (4 entities in total)
Functional Keywords	co-evolution, nucleocapdis, substrate recognition, hiv-1 protease, hydrolase-viral protein complex, hydrolase/viral protein
Total number of polymer chains	3
Total formula weight	23326.28
Authors	Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (deposition date: 2004-06-21, release date: 2005-03-29, Last modification date: 2023-08-23)
Primary citation	Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease J.Virol., 78:12446-12454, 2004 Cited by PubMed: 15507631 DOI: 10.1128/JVI.78.22.12446-12454.2004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation