1TP7

Crystal Structure of the RNA-dependent RNA Polymerase from Human Rhinovirus 16

Summary for 1TP7

• Entry DOI: 10.2210/pdb1tp7/pdb
• Descriptor: Genome polyprotein, SULFATE ION, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, ... (4 entities in total)
• Functional Keywords: rhinovirus, rna, polymerase, 3d, transferase
• Biological source: Human rhinovirus 16
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): Q82122
• Total number of polymer chains: 4
• Total formula weight: 211893.52

Authors

Appleby, T.C.,Luecke, H.,Shim, J.H.,Wu, J.Z.,Cheney, I.W.,Zhong, W.,Vogeley, L.,Hong, Z.,Yao, N. (deposition date: 2004-06-15, release date: 2005-06-21, Last modification date: 2011-07-13)

• Primary citation: Appleby, T.C.,Luecke, H.,Shim, J.H.,Wu, J.Z.,Cheney, I.W.,Zhong, W.,Vogeley, L.,Hong, Z.,Yao, N.; Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer.; J.Virol., 79:277-288, 2005; PubMed: 15596823; DOI: 10.1128/JVI.79.1.277-288.2005

Experimental method

X-RAY DIFFRACTION (2.4 Å)