1TOM

ALPHA-THROMBIN COMPLEXED WITH HIRUGEN

1TOM の概要

• エントリーDOI: 10.2210/pdb1tom/pdb
• 分子名称: ALPHA-THROMBIN, HIRUGEN, METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE, ... (5 entities in total)
• 機能のキーワード: hydrolase, serine protease, kringle, disease mutation, complex (hydrolase-inhibitor), hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
• 由来する生物種: Hirudo medicinalis (medicinal leech); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28507
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35869.90

構造登録者

Chen, Z. (登録日: 1996-12-06, 公開日: 1997-03-12, 最終更新日: 2024-10-23)

• 主引用文献: Lyle, T.A.,Chen, Z.G.,Appleby, S.D.,Freidinger, R.M.,Gardell, S.J.,Lewis, S.D.,Li, Y.,Lyle, E.A.,Lynch, J.J.,Mulichak, A.M.,Ng, A.S.,NaylorOlsen, A.M.,Sanders, W.M.; Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor.; Bioorg.Med.Chem.Lett., 7:67-72, 1997

実験手法

X-RAY DIFFRACTION (1.8 Å)