1TMB

MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A

1TMB の概要

• エントリーDOI: 10.2210/pdb1tmb/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000428
• 分子名称: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (5 entities in total)
• 機能のキーワード: serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P09945
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 36260.23

構造登録者

Qiu, X.,Padmanabhan, K.P.,Maryanoff, B.E.,Tulinsky, A. (登録日: 1993-05-27, 公開日: 1994-01-31, 最終更新日: 2023-11-15)

• 主引用文献: Maryanoff, B.E.,Qiu, X.,Padmanabhan, K.P.,Tulinsky, A.,Almond Jr., H.R.,Andrade-Gordon, P.,Greco, M.N.,Kauffman, J.A.,Nicolaou, K.C.,Liu, A.; Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.; Proc.Natl.Acad.Sci.USA, 90:8048-8052, 1993; PubMed: 8367461; DOI: 10.1073/pnas.90.17.8048

実験手法

X-RAY DIFFRACTION (2.3 Å)