1TLC
THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89
Summary for 1TLC
Entry DOI | 10.2210/pdb1tlc/pdb |
Descriptor | THYMIDYLATE SYNTHASE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (4 entities in total) |
Functional Keywords | methyltransferase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 62782.77 |
Authors | Weichsel, A.,Montfort, W.R.,Ciesla, J.,Maley, F. (deposition date: 1995-03-07, release date: 1995-06-03, Last modification date: 2018-04-18) |
Primary citation | Weichsel, A.,Montfort, W.R.,Ciesla, J.,Maley, F. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc.Natl.Acad.Sci.USA, 92:3493-3497, 1995 Cited by PubMed: 7724588DOI: 10.1073/pnas.92.8.3493 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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