1TG2

Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound

1TG2 の概要

• エントリーDOI: 10.2210/pdb1tg2/pdb
• 関連するPDBエントリー: 1LRM 1PAH 1TDW
• 分子名称: Phenylalanine-4-hydroxylase, FE (III) ION, 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, ... (4 entities in total)
• 機能のキーワード: phenylalanine hydroxylase phenylketonuria mutant a313t in complex with cofactor analogue 7, 8-dihydrobiopterin, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36025.62

構造登録者

Erlandsen, H.,Pey, A.L.,Gamez, A.,Perez, B.,Desviat, L.R.,Aguado, C.,Koch, R.,Surendran, S.,Tyring, S.,Matalon, R.,Scriver, C.R.,Ugarte, M.,Martinez, A.,Stevens, R.C. (登録日: 2004-05-28, 公開日: 2004-11-30, 最終更新日: 2023-08-23)

• 主引用文献: Erlandsen, H.,Pey, A.L.,Gamez, A.,Perez, B.,Desviat, L.R.,Aguado, C.,Koch, R.,Surendran, S.,Tyring, S.,Matalon, R.,Scriver, C.R.,Ugarte, M.,Martinez, A.,Stevens, R.C.; Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.; Proc.Natl.Acad.Sci.Usa, 101:16903-16908, 2004; PubMed: 15557004; DOI: 10.1073/pnas.0407256101

実験手法

X-RAY DIFFRACTION (2.2 Å)