1TF3

TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES

Summary for 1TF3

• Entry DOI: 10.2210/pdb1tf3/pdb
• Descriptor: 5S RNA GENE, TRANSCRIPTION FACTOR IIIA, ZINC ION, ... (4 entities in total)
• Functional Keywords: tfiiia, protein, dna, transcription factor, 5s rna gene, dna binding protein, zinc finger, complex (transcription regulation-dna), transcription-dna complex, transcription/dna
• Biological source: Xenopus laevis (African clawed frog); More
• Cellular location: Nucleus: P03001
• Total number of polymer chains: 3
• Total formula weight: 20062.42

Authors

Foster, M.P.,Wuttke, D.S.,Radhakrishnan, I.,Case, D.A.,Gottesfeld, J.M.,Wright, P.E. (deposition date: 1997-07-01, release date: 1997-09-17, Last modification date: 2024-05-22)

Primary citation

Foster, M.P.,Wuttke, D.S.,Radhakrishnan, I.,Case, D.A.,Gottesfeld, J.M.,Wright, P.E.
Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.
Nat.Struct.Biol., 4:605-608, 1997

PubMed Abstract: The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

PubMed: 9253405
DOI: 10.1038/nsb0897-605

Experimental method

SOLUTION NMR