1TCX
HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386
Summary for 1TCX
| Entry DOI | 10.2210/pdb1tcx/pdb |
| Descriptor | HIV PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total) |
| Functional Keywords | aids, polyprotein, hydrolase, aspartyl protease, endonuclease, rna-directed dna polymerase, acid protease, hydrolase (acid protease) |
| Biological source | Human immunodeficiency virus 1 |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
| Total number of polymer chains | 2 |
| Total formula weight | 22170.26 |
| Authors | Hoog, S.S.,Abdel-Meguid, S.S. (deposition date: 1996-06-05, release date: 1996-12-07, Last modification date: 2024-02-14) |
| Primary citation | Hoog, S.S.,Towler, E.M.,Zhao, B.,Doyle, M.L.,Debouck, C.,Abdel-Meguid, S.S. Human immunodeficiency virus protease ligand specificity conferred by residues outside of the active site cavity. Biochemistry, 35:10279-10286, 1996 Cited by PubMed: 8756683DOI: 10.1021/bi960179j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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