1TCX

HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	HIV PROTEASE	polymer	99	10817.8	2	UniProt (P04587) Pfam (PF00077) In PDB	Human immunodeficiency virus 1
2	A	(2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE	non-polymer		534.7	1	Chemie (IM1)
3		water	water		18.0	37	Chemie (HOH)

Sequence modifications

A, B: 1 - 99 (UniProt: P04587)

PDB	External Database	Details
Ile 32	Val 100	engineered mutation
Val 47	Ile 115	engineered mutation
Ile 82	Val 150	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21635.6
Non-Polymers*	Number of molecules	1
	Total formula weight	534.7
All*	Total formula weight	22170.3

*Water molecules are not included.