1TCW

SIV PROTEASE COMPLEXED WITH INHIBITOR SB203386

Summary for 1TCW

Entry DOI	10.2210/pdb1tcw/pdb
Descriptor	SIV PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total)
Functional Keywords	aids, polyprotein, hydrolase, aspartyl protease, endonuclease, rna-directed dna polymerase, acid protease, hydrolase (acid protease)
Biological source	Simian immunodeficiency virus
Total number of polymer chains	2
Total formula weight	22520.28
Authors	Hoog, S.S.,Abdel-Meguid, S.S. (deposition date: 1996-06-05, release date: 1996-12-07, Last modification date: 2024-02-14)
Primary citation	Hoog, S.S.,Towler, E.M.,Zhao, B.,Doyle, M.L.,Debouck, C.,Abdel-Meguid, S.S. Human immunodeficiency virus protease ligand specificity conferred by residues outside of the active site cavity. Biochemistry, 35:10279-10286, 1996 Cited by PubMed: 8756683 DOI: 10.1021/bi960179j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation