1TBG

BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN

1TBG の概要

• エントリーDOI: 10.2210/pdb1tbg/pdb
• 分子名称: TRANSDUCIN (3 entities in total)
• 機能のキーワード: complex (gtp-binding-transducer), eye, transducer, prenylation, complex (gtp-binding-transducer) complex, complex (gtp-binding/transducer)
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P02698
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 181588.46

構造登録者

Sondek, J.S.,Bohm, A.,Lambright, D.G.,Hamm, H.E.,Sigler, P.B. (登録日: 1996-06-15, 公開日: 1997-04-01, 最終更新日: 2024-02-14)

主引用文献

Sondek, J.,Bohm, A.,Lambright, D.G.,Hamm, H.E.,Sigler, P.B.
Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
Nature, 379:369-374, 1996

PubMed Abstract: Many signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals into intracellular responses. Upon nucleotide exchange catalysed by activated receptors, heterotrimers dissociate into GTP-bound G alpha subunits and G beta gamma dimers, either of which can modulate many downstream effectors. Here we use multiwavelength anomalous diffraction data to solve the crystal structure of the beta gamma dimer of the G protein transducin. The beta-subunit is primarily a seven-bladed beta-propeller that is partially encircled by an extended gamma-subunit. The beta-propeller, which contains seven structurally similar WD repeats, defines the stereochemistry of the WD repeat and the probable architecture of all WD-repeat-containing domains. The structure details interactions between G protein beta- and gamma-subunits and highlights regions implicated in effector modulation for the conserved family of G protein beta gamma dimers.

PubMed: 8552196
DOI: 10.1038/379369a0

実験手法

X-RAY DIFFRACTION (2.1 Å)