1T4V
Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin
Summary for 1T4V
Entry DOI | 10.2210/pdb1t4v/pdb |
Descriptor | Prothrombin, Hirudin IIIA, N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28507 |
Total number of polymer chains | 3 |
Total formula weight | 34742.11 |
Authors | Spurlino, J. (deposition date: 2004-04-30, release date: 2005-03-22, Last modification date: 2023-11-15) |
Primary citation | Lu, T.,Markotan, T.,Coppo, F.,Tomczuk, B.,Crysler, C.,Eisennagel, S.,Spurlino, J.,Gremminger, L.,Soll, R.M.,Giardino, E.C.,Bone, R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis BIOORG.MED.CHEM.LETT., 14:3727-3731, 2004 Cited by PubMed: 15203151DOI: 10.1016/j.bmcl.2004.05.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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