1T41
Crystal structure of human aldose reductase complexed with NADP and IDD552
Summary for 1T41
Entry DOI | 10.2210/pdb1t41/pdb |
Related | 1T40 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID, ... (4 entities in total) |
Functional Keywords | aldose reductase, atomic resolution, ternary complex, inhibitor binding, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37056.08 |
Authors | Ruiz, F.,Hazemann, I.,Mitschler, A.,Chevrier, B.,Schneider, T.,Joachimiak, A.,Karplus, M.,Podjarny, A. (deposition date: 2004-04-28, release date: 2004-08-03, Last modification date: 2024-04-03) |
Primary citation | Ruiz, F.,Hazemann, I.,Mitschler, A.,Joachimiak, A.,Schneider, T.,Karplus, M.,Podjarny, A. The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48. Acta Crystallogr.,Sect.D, 60:1347-1354, 2004 Cited by PubMed: 15272156DOI: 10.1107/S0907444904011370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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