1T41
Crystal structure of human aldose reductase complexed with NADP and IDD552
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldose reductase | polymer | 316 | 35898.3 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (human) | AR, Aldehyde reductase |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | C (A) | [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID | non-polymer | 414.3 | 1 | Chemie (ID5) | |||
| 4 | D (A) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
A: 1001 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 4 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35898.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1157.7 | |
| All* | Total formula weight | 37056.1 |
