1T3R
HIV protease wild-type in complex with TMC114 inhibitor
Summary for 1T3R
Entry DOI | 10.2210/pdb1t3r/pdb |
Related | 1F7A 1T7I 1T7J |
Descriptor | protease RETROPEPSIN, PHOSPHATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total) |
Functional Keywords | hiv-1 protease; drug resistance; thermodynamics; substrate envelope, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22626.05 |
Authors | King, N.M.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Wigernick, P.B.,de Bethune, M.P.,Schiffer, C.A. (deposition date: 2004-04-27, release date: 2005-05-03, Last modification date: 2023-08-23) |
Primary citation | Surleraux, D.L.,Tahri, A.,Verschueren, W.G.,Pille, G.M.,de Kock, H.A.,Jonckers, T.H.,Peeters, A.,De Meyer, S.,Azijn, H.,Pauwels, R.,de Bethune, M.P.,King, N.M.,Prabu-Jeyabalan, M.,Schiffer, C.A.,Wigerinck, P.B. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor J.Med.Chem., 48:1813-1822, 2005 Cited by PubMed: 15771427DOI: 10.1021/jm049560p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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