1T31

A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation

1T31 の概要

• エントリーDOI: 10.2210/pdb1t31/pdb
• 関連するPDBエントリー: 1PJP
• 分子名称: Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: human chymase, serine proteinase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27234.77

構造登録者

de Garavilla, L.,Greco, M.N.,Giardino, E.C.,Wells, G.I.,Haertlein, B.J.,Kauffman, J.A.,Corcoran, T.W.,Derian, C.K.,Eckardt, A.J.,Abraham, W.M.,Sukumar, N.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.,Andrade-Gordon, P.,Damiano, B.P.,Maryanoff, B.E.,Pereira, P.J.B.,Wang, Z.M.,Rubin, H.,Huber, R.,Bode, W.,Schechter, N.M.,Strobl, S. (登録日: 2004-04-23, 公開日: 2005-03-01, 最終更新日: 2023-08-23)

• 主引用文献: de Garavilla, L.,Greco, M.N.,Sukumar, N.,Chen, Z.W.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.,Giardino, E.C.,Wells, G.I.,Haertlein, B.J.,Kauffman, J.A.,Corcoran, T.W.,Derian, C.K.,Eckardt, A.J.,Damiano, B.P.,Andrade-Gordon, P.,Maryanoff, B.E.; A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.; J.Biol.Chem., 280:18001-18007, 2005; PubMed: 15741158; DOI: 10.1074/jbc.M501302200

実験手法

X-RAY DIFFRACTION (1.9 Å)