1T15
Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase
Summary for 1T15
Entry DOI | 10.2210/pdb1t15/pdb |
Descriptor | Breast cancer type 1 susceptibility protein, BRCA1 interacting protein C-terminal helicase 1 (3 entities in total) |
Functional Keywords | protein-peptide complex, antitumor protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus. Isoform 3: Cytoplasm. Isoform 5: Cytoplasm: P38398 |
Total number of polymer chains | 2 |
Total formula weight | 25493.16 |
Authors | Clapperton, J.A.,Manke, I.A.,Lowery, D.M.,Ho, T.,Haire, L.F.,Yaffe, M.B.,Smerdon, S.J. (deposition date: 2004-04-15, release date: 2004-05-11, Last modification date: 2011-07-13) |
Primary citation | Clapperton, J.A.,Manke, I.A.,Lowery, D.M.,Ho, T.,Haire, L.F.,Yaffe, M.B.,Smerdon, S.J. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer Nat.Struct.Mol.Biol., 11:512-518, 2004 Cited by PubMed: 15133502DOI: 10.1038/nsmb775 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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