1SZO

Crystal Structure Analysis of the 6-Oxo Camphor Hydrolase His122Ala Mutant Bound to Its Natural Product (2S,4S)-alpha-Campholinic Acid

Summary for 1SZO

• Entry DOI: 10.2210/pdb1szo/pdb
• Related: 1DUB 1O8U
• Descriptor: 6-oxocamphor hydrolase, (2S,4S)-4-(2,2-DIHYDROXYETHYL)-2,3,3-TRIMETHYLCYCLOPENTANONE, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: enzyme-product complex, hydrolase
• Biological source: Rhodococcus sp. NCIMB 9784
• Total number of polymer chains: 12
• Total formula weight: 343749.35

Authors

Leonard, P.M.,Grogan, G. (deposition date: 2004-04-06, release date: 2004-06-29, Last modification date: 2023-08-23)

• Primary citation: Leonard, P.M.,Grogan, G.; Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog.; J.Biol.Chem., 279:31312-31317, 2004; PubMed: 15138275; DOI: 10.1074/jbc.M403514200

Experimental method

X-RAY DIFFRACTION (1.9 Å)