1SZM
DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)
Summary for 1SZM
Entry DOI | 10.2210/pdb1szm/pdb |
Related | 1stc |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE (3 entities in total) |
Functional Keywords | pka, pkc, bisindolyl maleimide 2, ly333531, selectivity, surrogate kinase, amino acid residue exchange, transferase |
Biological source | Bos taurus (cattle) |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 82431.89 |
Authors | Gassel, M.,Breitenlechner, C.B.,Koenig, N.,Huber, R.,Engh, R.A.,Bossemeyer, D. (deposition date: 2004-04-06, release date: 2004-06-01, Last modification date: 2023-08-23) |
Primary citation | Gassel, M.,Breitenlechner, C.B.,Koenig, N.,Huber, R.,Engh, R.A.,Bossemeyer, D. The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase a. J.Biol.Chem., 279:23679-23690, 2004 Cited by PubMed: 14996846DOI: 10.1074/jbc.M314082200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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