1SZM

DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)

1SZM の概要

• エントリーDOI: 10.2210/pdb1szm/pdb
• 関連するPDBエントリー: 1stc
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE (3 entities in total)
• 機能のキーワード: pka, pkc, bisindolyl maleimide 2, ly333531, selectivity, surrogate kinase, amino acid residue exchange, transferase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82431.89

構造登録者

Gassel, M.,Breitenlechner, C.B.,Koenig, N.,Huber, R.,Engh, R.A.,Bossemeyer, D. (登録日: 2004-04-06, 公開日: 2004-06-01, 最終更新日: 2023-08-23)

• 主引用文献: Gassel, M.,Breitenlechner, C.B.,Koenig, N.,Huber, R.,Engh, R.A.,Bossemeyer, D.; The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase a.; J.Biol.Chem., 279:23679-23690, 2004; PubMed: 14996846; DOI: 10.1074/jbc.M314082200

実験手法

X-RAY DIFFRACTION (2.5 Å)