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1SYK

Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation

Summary for 1SYK
Entry DOI10.2210/pdb1syk/pdb
Related1APM 1ATP 1CTP 1J3H
DescriptorcAMP-dependent protein kinase, alpha-catalytic subunit (2 entities in total)
Functional Keywordse230q mutant; catalytic subunit; camp-dependent protein kinase; apoenzyme conformation; n-terminal a-helix, transferase
Biological sourceMus musculus (house mouse)
Cellular locationCytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132
Total number of polymer chains2
Total formula weight81312.66
Authors
Wu, J.,Yang, J.,Madhusudan, N.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S. (deposition date: 2004-04-01, release date: 2005-05-17, Last modification date: 2023-08-23)
Primary citationWu, J.,Yang, J.,Kannan, N.,Madhusudan, N.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S.
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
Protein Sci., 14:2871-2879, 2005
Cited by
PubMed: 16253959
DOI: 10.1110/ps.051715205
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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