1SYK

Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation

1SYK の概要

• エントリーDOI: 10.2210/pdb1syk/pdb
• 関連するPDBエントリー: 1APM 1ATP 1CTP 1J3H
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit (2 entities in total)
• 機能のキーワード: e230q mutant; catalytic subunit; camp-dependent protein kinase; apoenzyme conformation; n-terminal a-helix, transferase
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81312.66

構造登録者

Wu, J.,Yang, J.,Madhusudan, N.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S. (登録日: 2004-04-01, 公開日: 2005-05-17, 最終更新日: 2023-08-23)

• 主引用文献: Wu, J.,Yang, J.,Kannan, N.,Madhusudan, N.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S.; Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.; Protein Sci., 14:2871-2879, 2005; PubMed: 16253959; DOI: 10.1110/ps.051715205

実験手法

X-RAY DIFFRACTION (2.8 Å)