1SRS

SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA

1SRS の概要

• エントリーDOI: 10.2210/pdb1srs/pdb
• 分子名称: DNA (5'-D(*CP*CP*(5IU)P*TP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*A P*AP*G)-3'), PROTEIN (SERUM RESPONSE FACTOR (SRF)) (3 entities in total)
• 機能のキーワード: transcription regulation, mads-domain, complex (dna binding protein-dna), transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P11831
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 32321.66

構造登録者

Pellegrini, L.,Tan, S.,Richmond, T.J. (登録日: 1995-07-28, 公開日: 1995-07-28, 最終更新日: 2024-02-14)

主引用文献

Pellegrini, L.,Tan, S.,Richmond, T.J.
Structure of serum response factor core bound to DNA.
Nature, 376:490-498, 1995

PubMed Abstract: The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

PubMed: 7637780
DOI: 10.1038/376490a0

実験手法

X-RAY DIFFRACTION (3.2 Å)