1SP4
Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft
Summary for 1SP4
Entry DOI | 10.2210/pdb1sp4/pdb |
Related PRD ID | PRD_000444 |
Descriptor | Cathepsin B, methyl N-[(2S)-4-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]amino}-2-hydroxy-4-oxobutanoyl]-L-leucylglycylglycinate, ... (4 entities in total) |
Functional Keywords | cathepsin b, epoxysuccinyl-based inhibitors, inhibitor design, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (cattle) More |
Cellular location | Lysosome : P07688 P07688 |
Total number of polymer chains | 2 |
Total formula weight | 28118.24 |
Authors | Stern, I.,Schaschke, N.,Moroder, L.,Turk, D. (deposition date: 2004-03-16, release date: 2004-05-04, Last modification date: 2024-03-13) |
Primary citation | Stern, I.,Schaschke, N.,Moroder, L.,Turk, D. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. Biochem.J., 381:511-517, 2004 Cited by PubMed: 15084146DOI: 10.1042/BJ20040237 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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