1SO2

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR

Summary for 1SO2

Entry DOI	10.2210/pdb1so2/pdb
Related	1soj
Descriptor	cGMP-inhibited 3',5'-cyclic phosphodiesterase B, MAGNESIUM ION, 1-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL, ... (5 entities in total)
Functional Keywords	pde3b phosphodiesterase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Multi-pass membrane protein (Potential): Q13370
Total number of polymer chains	4
Total formula weight	196369.20
Authors	Scapin, G.,Patel, S.B.,Chung, C.,Varnerin, J.P.,Edmondson, S.D.,Mastracchio, A.,Parmee, E.R.,Becker, J.W.,Singh, S.B.,Van Der Ploeg, L.H.,Tota, M.R. (deposition date: 2004-03-12, release date: 2004-05-11, Last modification date: 2023-08-23)
Primary citation	Scapin, G.,Patel, S.B.,Chung, C.,Varnerin, J.P.,Edmondson, S.D.,Mastracchio, A.,Parmee, E.R.,Singh, S.B.,Becker, J.W.,Van Der Ploeg, L.H.,Tota, M.R. Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity Biochemistry, 43:6091-6100, 2004 Cited by PubMed: 15147193 DOI: 10.1021/bi049868i PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation