1SJ0

Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D

1SJ0 の概要

• エントリーDOI: 10.2210/pdb1sj0/pdb
• 分子名称: Estrogen receptor, (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28779.91

構造登録者

Kim, S.,Wu, J.Y.,Birzin, E.T.,Chan, W.,Pai, L.Y.,Yang, Y.T.,Mosley, R.T.,Fitzgerald, P.M.,Sharma, N.,DiNinno, F.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L. (登録日: 2004-03-02, 公開日: 2004-04-27, 最終更新日: 2024-02-14)

• 主引用文献: Kim, S.,Wu, J.Y.,Birzin, E.T.,Frisch, K.,Chan, W.,Pai, L.Y.,Yang, Y.T.,Mosley, R.T.,Fitzgerald, P.M.,Sharma, N.,Dahllund, J.,Thorsell, A.G.,DiNinno, F.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L.; Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators.; J.Med.Chem., 47:2171-2175, 2004; PubMed: 15084115; DOI: 10.1021/jm034243o

実験手法

X-RAY DIFFRACTION (1.9 Å)