1SIV
THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS
Summary for 1SIV
Entry DOI | 10.2210/pdb1siv/pdb |
Related PRD ID | PRD_000320 |
Descriptor | SIV PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor |
Biological source | Simian immunodeficiency virus |
Total number of polymer chains | 2 |
Total formula weight | 22028.61 |
Authors | Zhao, B.,Abdel-Meguid, S. (deposition date: 1993-08-24, release date: 1994-01-31, Last modification date: 2024-02-14) |
Primary citation | Zhao, B.,Winborne, E.,Minnich, M.D.,Culp, J.S.,Debouck, C.,Abdel-Meguid, S.S. Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors. Biochemistry, 32:13054-13060, 1993 Cited by PubMed: 8241159DOI: 10.1021/bi00211a015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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