1SIV

THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS

Summary for 1SIV

Entry DOI	10.2210/pdb1siv/pdb
Related PRD ID	PRD_000320
Descriptor	SIV PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
Biological source	Simian immunodeficiency virus
Total number of polymer chains	2
Total formula weight	22028.61
Authors	Zhao, B.,Abdel-Meguid, S. (deposition date: 1993-08-24, release date: 1994-01-31, Last modification date: 2024-02-14)
Primary citation	Zhao, B.,Winborne, E.,Minnich, M.D.,Culp, J.S.,Debouck, C.,Abdel-Meguid, S.S. Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors. Biochemistry, 32:13054-13060, 1993 Cited by PubMed: 8241159 DOI: 10.1021/bi00211a015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation