1SIV

THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS

1SIV の概要

• エントリーDOI: 10.2210/pdb1siv/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000320
• 分子名称: SIV PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
• 由来する生物種: Simian immunodeficiency virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22028.61

構造登録者

Zhao, B.,Abdel-Meguid, S. (登録日: 1993-08-24, 公開日: 1994-01-31, 最終更新日: 2024-02-14)

• 主引用文献: Zhao, B.,Winborne, E.,Minnich, M.D.,Culp, J.S.,Debouck, C.,Abdel-Meguid, S.S.; Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors.; Biochemistry, 32:13054-13060, 1993; PubMed: 8241159; DOI: 10.1021/bi00211a015

実験手法

X-RAY DIFFRACTION (2.5 Å)