1SIE

MURINE POLYOMAVIRUS COMPLEXED WITH A DISIALYLATED OLIGOSACCHARIDE

Summary for 1SIE

• Entry DOI: 10.2210/pdb1sie/pdb
• Descriptor: POLYOMAVIRUS COAT PROTEIN VP1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: coat protein, icosahedral virus, virus
• Biological source: Mouse polyomavirus (strain p16 small-plaque)
• Cellular location: Virion: P49302
• Total number of polymer chains: 6
• Total formula weight: 260225.80

Authors

Stehle, T.,Harrison, S.C. (deposition date: 1995-12-12, release date: 1996-06-20, Last modification date: 2024-11-13)

Primary citation

Stehle, T.,Harrison, S.C.
Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments.
Structure, 4:183-194, 1996

PubMed Abstract: Murine polyomavirus recognizes (alpha2,3)-linked alpha-5-N-acetylneuraminic acid (sialic acid) on the surface of susceptible cells. While all strains bind to straight-chain receptors terminating in (alpha2,3)-linked sialic acid, some strains also bind to branched oligosaccharides that carry a second, (alpha2,6)-linked sialic acid. The ability to bind to these branched-chain receptors correlates with a single amino acid mutation at position 91 on the outer surface of the major capsid protein, VP1, and with a significant decrease in tumorigenicity.

PubMed: 8805524
DOI: 10.1016/S0969-2126(96)00021-4

Experimental method

X-RAY DIFFRACTION (3.65 Å)