1SHZ

Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera

Summary for 1SHZ

Entry DOI	10.2210/pdb1shz/pdb
Related	1AGR 1AZS 1FQJ 1IAP
Descriptor	Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera, Rho guanine nucleotide exchange factor 1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	signal transduction, protein complex, signaling protein
Biological source	Rattus norvegicus (house mouse, Norway rat) More
Cellular location	Nucleus: P10824 Cytoplasm : Q92888
Total number of polymer chains	4
Total formula weight	133115.10
Authors	Chen, Z.,Singer, W.D.,Sternweis, P.C.,Sprang, S.R. (deposition date: 2004-02-26, release date: 2005-01-18, Last modification date: 2023-08-23)
Primary citation	Chen, Z.,Singer, W.D.,Sternweis, P.C.,Sprang, S.R. Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator. Nat.Struct.Mol.Biol., 12:191-197, 2005 Cited by PubMed: 15665872 DOI: 10.1038/nsmb888 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation