1SGF

CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES)

Summary for 1SGF

• Entry DOI: 10.2210/pdb1sgf/pdb
• Descriptor: NERVE GROWTH FACTOR, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: growth factor (beta-ngf), hydrolase - serine proteinase (gamma-ngf), inactive serine proteinase (alpha-ngf), growth factor
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 134406.91

Authors

Bax, B.D.V.,Blundell, T.L.,Murray-Rust, J.,Mcdonald, N.Q. (deposition date: 1997-08-08, release date: 1998-05-27, Last modification date: 2023-08-09)

Primary citation

Bax, B.,Blundell, T.L.,Murray-Rust, J.,McDonald, N.Q.
Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Structure, 5:1275-1285, 1997

PubMed Abstract: Nerve growth factor (NGF) is a neurotrophic factor that promotes the differentiation and survival of certain populations of neurons in the central and peripheral nervous systems. 7S NGF is an alpha 2 beta 2 gamma 2 complex in which the beta-NGF dimer (the active neurotrophin) is associated with two alpha-NGF and two gamma-NGF subunits, which belong to the glandular kallikrein family of serine proteinases. The gamma-NGF subunit is an active serine proteinase capable of processing the precursor form of beta-NGF, whereas alpha-NGF is an inactive serine proteinase. The structure of 7S NGF could be used as a starting point to design inhibitors that prevent NGF binding to its receptors, as a potential treatment of neurodegenerative diseases.

PubMed: 9351801
DOI: 10.1016/S0969-2126(97)00280-3

Experimental method

X-RAY DIFFRACTION (3.15 Å)