1SGF
CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0005102 | molecular_function | signaling receptor binding |
| G | 0001669 | cellular_component | acrosomal vesicle |
| G | 0003073 | biological_process | regulation of systemic arterial blood pressure |
| G | 0004175 | molecular_function | endopeptidase activity |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0005615 | cellular_component | extracellular space |
| G | 0005634 | cellular_component | nucleus |
| G | 0006508 | biological_process | proteolysis |
| G | 0007165 | biological_process | signal transduction |
| G | 0008083 | molecular_function | growth factor activity |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0008236 | molecular_function | serine-type peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0030141 | cellular_component | secretory granule |
| G | 0031638 | biological_process | zymogen activation |
| G | 0045177 | cellular_component | apical part of cell |
| G | 0046872 | molecular_function | metal ion binding |
| X | 0004252 | molecular_function | serine-type endopeptidase activity |
| X | 0006508 | biological_process | proteolysis |
| Y | 0005102 | molecular_function | signaling receptor binding |
| Z | 0001669 | cellular_component | acrosomal vesicle |
| Z | 0003073 | biological_process | regulation of systemic arterial blood pressure |
| Z | 0004175 | molecular_function | endopeptidase activity |
| Z | 0004252 | molecular_function | serine-type endopeptidase activity |
| Z | 0005615 | cellular_component | extracellular space |
| Z | 0005634 | cellular_component | nucleus |
| Z | 0006508 | biological_process | proteolysis |
| Z | 0007165 | biological_process | signal transduction |
| Z | 0008083 | molecular_function | growth factor activity |
| Z | 0008233 | molecular_function | peptidase activity |
| Z | 0008236 | molecular_function | serine-type peptidase activity |
| Z | 0016787 | molecular_function | hydrolase activity |
| Z | 0030141 | cellular_component | secretory granule |
| Z | 0031638 | biological_process | zymogen activation |
| Z | 0045177 | cellular_component | apical part of cell |
| Z | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 | |
| G | LEU53-CYS58 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DTckGDSGGPLI |
| Chain | Residue | Details |
| G | ASP189-ILE200 |
| site_id | PS00248 |
| Number of Residues | 14 |
| Details | NGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC |
| Chain | Residue | Details |
| B | GLY67-CYS80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"22649032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EAX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"26144237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XPJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22649032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EAX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 298 |
| Details | Region: {"description":"Segment A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 104 |
| Details | Region: {"description":"Segment C"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 192 |
| Details | Region: {"description":"Segment B2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"7263706","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| G | ASP102 | |
| G | SER195 | |
| G | HIS57 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| X | ASP102 | |
| X | SER195 | |
| X | HIS57 | |
| X | GLY196 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| G | ASP102 | |
| G | SER195 | |
| G | HIS57 | |
| G | GLY196 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| Z | ASP102 | |
| Z | SER195 | |
| Z | HIS57 | |
| Z | GLY196 |
| site_id | CSA13 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY187 | |
| A | SER195 | |
| A | HIS57 | |
| A | SER214 | |
| A | ASP93 |
| site_id | CSA14 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| X | GLY187 | |
| X | SER195 | |
| X | HIS57 | |
| X | SER214 | |
| X | ASP93 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| Z | ASP102 | |
| Z | SER195 | |
| Z | HIS57 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| X | ASP102 | |
| X | SER195 | |
| X | HIS57 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS193 | |
| A | HIS57 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| X | ASP102 | |
| X | SER195 | |
| X | HIS193 | |
| X | HIS57 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| G | ASP102 | |
| G | SER195 | |
| G | GLY193 | |
| G | HIS57 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| Z | ASP102 | |
| Z | SER195 | |
| Z | GLY193 | |
| Z | HIS57 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 |
