1SG1

Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75

1SG1 の概要

• エントリーDOI: 10.2210/pdb1sg1/pdb
• 分子名称: Beta-nerve growth factor, Tumor necrosis factor receptor superfamily member 16, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: nerve growth factor, ngf, p75, neurotrophin, common neurotrophin receptor, growth factor receptor, receptor-ligand complex, hormone-growth factor-membrane protein complex, hormone/growth factor/membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01138; Membrane; Single-pass type I membrane protein: P07174
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44324.29

構造登録者

He, X.L.,Garcia, K.C. (登録日: 2004-02-22, 公開日: 2004-06-01, 最終更新日: 2023-08-23)

主引用文献

He, X.L.,Garcia, K.C.
Structure of nerve growth factor complexed with the shared neurotrophin receptor p75
Science, 304:870-875, 2004

PubMed Abstract: Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 A crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a single p75. p75 binds along the homodimeric interface of NGF, which disables NGF's symmetry-related second p75 binding site through an allosteric conformational change. Thus, neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.

PubMed: 15131306
DOI: 10.1126/science.1095190

実験手法

X-RAY DIFFRACTION (2.4 Å)