1SEJ

Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP

1SEJ の概要

• エントリーDOI: 10.2210/pdb1sej/pdb
• 関連するPDBエントリー: 1qzf
• 分子名称: bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (5 entities in total)
• 機能のキーワード: bifunctional enzyme, transferase, oxidoreductase
• 由来する生物種: Cryptosporidium hominis
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 311585.64

構造登録者

Anderson, A.C. (登録日: 2004-02-17, 公開日: 2004-05-18, 最終更新日: 2023-08-23)

• 主引用文献: Anderson, A.C.; Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.; Acta Crystallogr.,Sect.F, 61:258-262, 2005; PubMed: 16511011; DOI: 10.1107/S1744309105002435

実験手法

X-RAY DIFFRACTION (2.87 Å)