1SEJ
Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 521 | 60262.5 | 5 | UniProt (Q27552) Pfam (PF00186) Pfam (PF00303) In PDB | Cryptosporidium hominis | |
| 2 | A, B, C, D, E | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 5 | Chemie (UMP) | |||
| 3 | A, B, C, D, E | S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID | non-polymer | 500.5 | 10 | Chemie (F89) | |||
| 4 | A, B, C, D, E | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
| 5 | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 301312.6 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 10273.0 | |
| All* | Total formula weight | 311585.6 |
