1SC7

Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex

Summary for 1SC7

• Entry DOI: 10.2210/pdb1sc7/pdb
• Related: 1K4S 1K4T
• Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (6 entities in total)
• Functional Keywords: complex (isomerase-dna), dna, topoisomerase i, drug, poison, idenoisoquinoline, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 4
• Total formula weight: 84243.52

Authors

Staker, B.L.,Feese, M.D.,Cushman, M.,Pommier, Y.,Zembower, D.,Stewart, L.,Burgin, A.B. (deposition date: 2004-02-11, release date: 2005-04-19, Last modification date: 2011-07-13)

• Primary citation: Staker, B.L.,Feese, M.D.,Cushman, M.,Pommier, Y.,Zembower, D.,Stewart, L.,Burgin, A.B.; Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex; J.Med.Chem., 48:2336-2345, 2005; PubMed: 15801827; DOI: 10.1021/jm049146p

Experimental method

X-RAY DIFFRACTION (3 Å)