1SC7
Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3' | polymer | 10 | 3061.1 | 1 | |||
| 2 | B (C) | 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' | polymer | 12 | 3716.5 | 1 | |||
| 3 | C (D) | 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6690.4 | 1 | |||
| 4 | D (A) | DNA topoisomerase I | polymer | 592 | 70248.0 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) | Homo sapiens (human) | |
| 5 | E (C) | 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE | non-polymer | 333.3 | 1 | Chemie (M38) | |||
| 6 | F (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) |
Sequence modifications
A: 174 - 765 (UniProt: P11387)
| PDB | External Database | Details |
|---|---|---|
| Ptr 723 | Tyr 723 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 83716.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 527.6 | |
| All* | Total formula weight | 84243.5 |
