1SBG

AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS

1SBG の概要

• エントリーDOI: 10.2210/pdb1sbg/pdb
• 分子名称: HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total)
• 機能のキーワード: hydrolase(acid protease)
• 由来する生物種: Human immunodeficiency virus type 1 BH10
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22196.25

構造登録者

Abdel-Meguid, S.,Zhao, B. (登録日: 1994-05-24, 公開日: 1994-10-15, 最終更新日: 2024-02-14)

• 主引用文献: Abdel-Meguid, S.S.,Metcalf, B.W.,Carr, T.J.,Demarsh, P.,DesJarlais, R.L.,Fisher, S.,Green, D.W.,Ivanoff, L.,Lambert, D.M.,Murthy, K.H.M.,Petteway Jr., S.R.,Pitts, W.J.,Tomaszek Jr., T.A.,Winborne, E.,Zhao, B.,Dreyer, G.B.,Meek, T.D.; An orally bioavailable HIV-1 protease inhibitor containing an imidazole-derived peptide bond replacement: crystallographic and pharmacokinetic analysis.; Biochemistry, 33:11671-11677, 1994; PubMed: 7918383; DOI: 10.1021/bi00205a001

実験手法

X-RAY DIFFRACTION (2.3 Å)