1S9J
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Summary for 1S9J
Entry DOI | 10.2210/pdb1s9j/pdb |
Related | 1S9I |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | protein kinase-ligand-mgatp complex, protein-protein interactions, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 39023.18 |
Authors | Ohren, J.F.,Chen, H.,Pavlovsky, A.,Whitehead, C.,Yan, C.,McConnell, P.,Delaney, A.,Dudley, D.T.,Sebolt-Leopold, J.,Hasemann, C.A. (deposition date: 2004-02-04, release date: 2004-11-23, Last modification date: 2024-04-03) |
Primary citation | Ohren, J.F.,Chen, H.,Pavlovsky, A.,Whitehead, C.,Zhang, E.,Kuffa, P.,Yan, C.,McConnell, P.,Spessard, C.,Banotai, C.,Mueller, W.T.,Delaney, A.,Omer, C.,Sebolt-Leopold, J.,Dudley, D.T.,Leung, I.K.,Flamme, C.,Warmus, J.,Kaufman, M.,Barrett, S.,Tecle, H.,Hasemann, C.A. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat.Struct.Mol.Biol., 11:1192-1197, 2004 Cited by PubMed: 15543157DOI: 10.1038/nsmb859 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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