1S9J

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity mitogen-activated protein kinase kinase 1	polymer	341	37930.6	1	UniProt (Q02750) Pfam (PF00069) In PDB	Homo sapiens (human)	MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
4	A	5-BROMO-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE	non-polymer		561.1	1	Chemie (BBM)
5		water	water		18.0	109	Chemie (HOH)

Sequence modifications

A: 62 - 393 (UniProt: Q02750)

PDB	External Database	Details
Met 61	-	initiating methionine
Leu 394	-	expression tag
Glu 395	-	expression tag
His 396	-	expression tag
His 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag
His 401	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37930.6
Non-Polymers*	Number of molecules	3
	Total formula weight	1092.6
All*	Total formula weight	39023.2

*Water molecules are not included.