1S78
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Summary for 1S78
Entry DOI | 10.2210/pdb1s78/pdb |
Related | 1L7I 1N8Y 1N8Z |
Descriptor | Receptor protein-tyrosine kinase erbB-2, Pertuzumab Fab light chain, Pertuzumab Fab heavy chain, ... (6 entities in total) |
Functional Keywords | receptor-antibody complex, fab fragment, cysteine-rich domain, leucine-rich repeat, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 235727.05 |
Authors | Franklin, M.C.,Carey, K.D.,Vajdos, F.F.,Leahy, D.J.,de Vos, A.M.,Sliwkowski, M.X. (deposition date: 2004-01-29, release date: 2004-04-27, Last modification date: 2023-08-23) |
Primary citation | Franklin, M.C.,Carey, K.D.,Vajdos, F.F.,Leahy, D.J.,De Vos, A.M.,Sliwkowski, M.X. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell, 5:317-328, 2004 Cited by PubMed: 15093539DOI: 10.1016/S1535-6108(04)00083-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
Download full validation report