1S78

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Receptor protein-tyrosine kinase erbB-2	polymer	624	68794.1	2	UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB	Homo sapiens (human)	p185erbB2, NEU proto-oncogene, C-erbB-2, Tyrosine kinase-type cell surface receptor HER2, MLN 19
2	C, E	Pertuzumab Fab light chain	polymer	214	23548.2	2	Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (Q7Z3Y4) In PDB	Mus musculus (house mouse)
3	D, F	Pertuzumab Fab heavy chain	polymer	226	24158.0	2		Mus musculus (house mouse)
4	G, H, I, K	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
5	J	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	233000.5
Branched	Number of molecules	5
	Total formula weight	2284.1
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	235727.1

*Water molecules are not included.