1S78
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor protein-tyrosine kinase erbB-2 | polymer | 624 | 68794.1 | 2 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | p185erbB2, NEU proto-oncogene, C-erbB-2, Tyrosine kinase-type cell surface receptor HER2, MLN 19 |
| 2 | C, E (C, E) | Pertuzumab Fab light chain | polymer | 214 | 23548.2 | 2 | UniProt (by SIFTS) (Q7Z3Y4) | Mus musculus (house mouse) | |
| 3 | D, F (D, F) | Pertuzumab Fab heavy chain | polymer | 226 | 24158.0 | 2 | Mus musculus (house mouse) | ||
| 4 | G, H, I, K (G, H, I, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J (J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | L, M (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 233000.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2284.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 235727.1 |
