1S2C

Crystal structures of prostaglandin D2 11-ketoreductase in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin

1S2C の概要

• エントリーDOI: 10.2210/pdb1s2c/pdb
• 関連するPDBエントリー: 1S1P 1S1R 1S2A
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, ... (5 entities in total)
• 機能のキーワード: tim-barrel, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39351.35

構造登録者

Lovering, A.L.,Ride, J.P.,Bunce, C.M.,Desmond, J.C.,Cummings, S.M.,White, S.A. (登録日: 2004-01-08, 公開日: 2004-03-23, 最終更新日: 2023-10-25)

• 主引用文献: Lovering, A.L.,Ride, J.P.,Bunce, C.M.,Desmond, J.C.,Cummings, S.M.,White, S.A.; Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin.; Cancer Res., 64:1802-1810, 2004; PubMed: 14996743; DOI: 10.1158/0008-5472.CAN-03-2847

実験手法

X-RAY DIFFRACTION (1.8 Å)