1RWQ

Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine

1RWQ の概要

• エントリーDOI: 10.2210/pdb1rwq/pdb
• 関連するPDBエントリー: 1NU6 1NU8
• 分子名称: Dipeptidyl peptidase IV, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE, ... (4 entities in total)
• 機能のキーワード: dipeptidyl peptidase iv, exopeptidase, adenosine binding, drug design, complex structure, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 171505.45

構造登録者

Hennig, M.,Thoma, R.,Stihle, M. (登録日: 2003-12-17, 公開日: 2004-12-17, 最終更新日: 2020-07-29)

• 主引用文献: Peters, J.U.,Weber, S.,Kritter, S.,Weiss, P.,Wallier, A.,Boehringer, M.,Hennig, M.,Kuhn, B.,Loeffler, B.M.; Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents; Bioorg.Med.Chem.Lett., 14:1491-1493, 2004; PubMed: 15006388; DOI: 10.1016/j.bmcl.2004.01.019

実験手法

X-RAY DIFFRACTION (2.2 Å)