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1RS2

DHNA complex with 8-Amino-1,3-dimethyl-3,7-dihydropurine-2,6-dione

Summary for 1RS2
Entry DOI10.2210/pdb1rs2/pdb
Related1RR5 1RRI 1RRW 1RRY 1RS4 1RSD 1RSI
DescriptorDihydroneopterin aldolase, 8-AMINO-1,3-DIMETHYL-3,7-DIHYDROPURINE-2,6-DIONE (3 entities in total)
Functional Keywordsdhna, 7, 8-dihydroneop8-amino-1, 3-dimethyl-3, 7-dihydropurine-2, 6-dioneterin aldolase, lyase
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight13964.81
Authors
Primary citationSanders, W.J.,Nienaber, V.L.,Lerner, C.G.,McCall, J.O.,Merrick, S.M.,Swanson, S.J.,Harlan, J.E.,Stoll, V.S.,Stamper, G.F.,Betz, S.F.,Condroski, K.R.,Meadows, R.P.,Severin, J.M.,Walter, K.A.,Magdalinos, P.,Jakob, C.G.,Wagner, R.,Beutel, B.A.
Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47:1709-1718, 2004
Cited by
PubMed: 15027862
DOI: 10.1021/jm030497y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.31 Å)
Structure validation

217705

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